期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 6, 页码 538-548出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36755f
关键词
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资金
- Dutch Foundation of Technical Sciences [10805]
- Netherlands Proteomics Centre embedded in the Netherlands Genomics Initiative
Monoclonal antibodies (mAbs) are important therapeutics, targeting a variety of diseases ranging from cancers to neurodegenerative disorders. In developmental stages and prior to clinical use, these molecules require thorough structural characterisation, but their large size and heterogeneity present challenges for most analytical techniques. Over the past 20 years, mass spectrometry (MS) has transformed from a tool for small molecule analysis to a technique that can be used to study large intact proteins and non-covalent protein complexes. Here, we review several MS-based techniques that have emerged for the analysis of intact mAbs and discuss the prospects of using these technologies for the analysis of biopharmaceuticals.
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