期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 59, 页码 7380-7382出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32757k
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资金
- Takeda Science Foundation
- MEXT [23750111]
- Asahi Glass Foundation
The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded the corresponding products, each bearing a trifluoromethylated stereogenic center with high optical purity. A resulting product was converted into an MAO-A inhibitor, befloxatone.
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