期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 47, 页码 5835-5837出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32149a
关键词
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资金
- NHLBI
- NIH [HHSN268201000045C, R01 EB009638, K99 EB012165, R01 CA155432]
- Netherlands Organization for Scientific Research (NWO) [ECHO.06.B.047]
Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.
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