期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 94, 页码 11519-11521出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36702e
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资金
- Ukrainian National Academy of Sciences [02-03-12]
Addition of anions derived from dialkyl methylphosphonates to (Ss)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine afforded (Ss, R) addition adducts in moderate to good yield (53-75%) with excellent diastereoselectivity (94-95% de). After selective removal of the N-sulfinyl group, dipeptides containing enantiomerically pure diethyl 2-amino-3,3,3-trifluoropropylphosphonate were synthesized to investigate the influence of the trifluoromethyl substituent on N-terminal coupling.
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