期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 25, 页码 3091-3093出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc18011a
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [Specially Promoted Research 22000006]
- Industrial Technology Development Organization (NEDO) of Japan
- Inoue Foundation for Science
- Konica Minolta Science and Technology Foundation
- Asahi Glass Foundation
- JSPS
- Grants-in-Aid for Scientific Research [22000006, 09J10632] Funding Source: KAKEN
We have designed and synthesized a reversible near-infrared (NIR) fluorescence probe, 2-Me TeR, for reactive oxygen species (ROS), utilizing the redox properties of the tellurium (Te) atom. 2-Me TeR is oxidized to fluorescent 2-Me TeOR by various ROS, while the generated 2-Me TeOR is quickly reduced in the presence of glutathione to regenerate 2-Me TeR. This redox-induced reversible NIR-fluorescence response of 2-Me TeR allowed us to detect the endogenous production of ROS and subsequent homeostatic recovery of the intracellular reductive environment in hydrogen peroxide-stimulated HL-60 cells. This probe is expected to be useful for monitoring the dynamics of ROS production continuously in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据