期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 85, 页码 10472-10480出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35042d
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资金
- National Key Scientific Program of China [2011CB911000]
- China National Instrumentation Program [2011YQ03012412]
- National Institutes of Health [GM066137, GM079359, CA133086]
- NATIONAL CANCER INSTITUTE [R01CA133086] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079359, R01GM066137] Funding Source: NIH RePORTER
The last two decades have witnessed the development and application of nucleic acid aptamers in a variety of fields, including target analysis, disease therapy, and molecular and cellular engineering. The efficient and widely applicable aptamer selection, reproducible chemical synthesis and modification, generally impressive target binding selectivity and affinity, relatively rapid tissue penetration, low immunogenicity, and rapid systemic clearance make aptamers ideal recognition elements for use as therapeutics or for in vivo delivery of therapeutics. In this feature article, we discuss the development and biomedical application of nucleic acid aptamers, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.
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