期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 84, 页码 10416-10418出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc35044k
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资金
- NCI NIH HHS [R15 CA135579] Funding Source: Medline
- NIGMS NIH HHS [P20 GM103451] Funding Source: Medline
A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.
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