期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 95, 页码 11623-11625出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36610j
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资金
- AIRC [IG-12085]
- Beneficentia Stiftung (Vaduz, Liechtenstein)
Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.
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