期刊
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
卷 38, 期 2, 页码 192-199出版社
LAWRENCE ERLBAUM ASSOC INC
DOI: 10.1207/S15327914NC382_8
关键词
-
The effects of oral administration of bovine lactoferrin (bLF) and its hydrolysate on the lung colonization by colon 26 carcinoma were investigated. At doses of 100 or 300 mg/kg/day for seven successive days, bLFs demonstrated a significant inhibitory effect on experimental metastasis, which indicated effectiveness before and after tumor implantation. Oral administration of bLFs augmented CD4(+), CD8(+), and asialoGM1(+) cells in the spleen and peripheral blood. Their cytotoxic activities against Yac-1 and colon 26 carcinoma were enhanced by HE In the small intestinal epithelium, CD4(+) and CD8(+) cells were markedly increased, and, simultaneously, enhanced production of interleukin-18 (IL-18) was confirmed in the intestinal epithelial cells. In this model, intravenous injection of marine IL-18 showed significant inhibition of the lung colonization by colon 26 carcinoma. These results suggested that inhibition of experimental metastasis by oral administration of bLF and pepsin hydrolysate of bLF might be due to enhanced cellular immunity; presumably mediated by enhanced IL-18 production in the intestinal epithelium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据