4.7 Article

An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction

期刊

CHEMICAL COMMUNICATIONS
卷 48, 期 35, 页码 4208-4210

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30997a

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资金

  1. China NSF [21075040, 31101285]
  2. Shanghai Fund [11 nm0502500, 11XD1401900, 09JC1404100]
  3. Fundamental Research Funds for the Central Universities

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We have developed a simple and ultrasensitive E-DNA sensor based on the ssDNA-assisted cascade of a hybridization reaction mechanism to form a long concatamers structure to improve its sensitivity, significantly. The proposed sensor was applied to sequence-specific DNA and ATP detection. Experimental results showed a quantitative measurement with the detection limit as low as 1 aM for specific DNA and 10 fM for ATP.

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