期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 83, 页码 10271-10279出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34739c
关键词
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资金
- Shanghai Municipal Committee of Science and Technology [11JC1402600]
- National Basic Research Program of China (973) [2009CB825300]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [21072206, 20472096, 20872162, 20672127, 21121062, 20732008]
Cycloisomerization of 1,n-enynes and diynes is a powerful method in organic synthesis to access heterocyclic compounds and has drawn increasing attention from organic chemists. In this paper, we attempted to summarize our recent results on the transition metal-catalyzed cycloisomerization to synthesize five or six-membered heterocyclic compounds using 1, n-enynes and diynes having a propargylic ester moiety. First, we will describe the synthesis of 2,3-disubstituted 3-pyrrolines via gold catalyzed cycloisomerization of 1,6-diynes. In addition, we will also disclose a novel silver catalyzed tandem 1,3-acyloxy migration/Mannich-type addition/elimination of the sulfonyl group of N-sulfonylhydrazone-propargylic esters to 5,6-dihydropyridazin-4-one derivatives. Furthermore, we will introduce three interesting examples of the synthesis of bicyclic compounds via titanium or rhodium catalyzed carbocyclization of enynes. In this context, we have presented that 1, n-enynes and diynes containing propargylic esters are highly reactive and useful starting materials for the cycloisomerization catalyzed by a transition metal catalyst.
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