期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 89, 页码 11014-11016出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34015a
关键词
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A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.
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