期刊
CELLULAR SIGNALLING
卷 12, 期 1, 页码 1-13出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0898-6568(99)00071-6
关键词
MAPK; p38; signalling
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041637] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI41637] Funding Source: Medline
- NIGMS NIH HHS [GM51470] Funding Source: Medline
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase pathway, plays an essential role in regulating many cellular processes including inflammation, cell differentiation, cell growth and death. Activation of p38 often through extracellular stimuli such as bacterial pathogens and cytokines, mediates signal transduction into the nucleus to turn on the responsive genes. p38 also transduces signals to other cellular components to execute different cellular responses. In this review, we summarize the characteristics of the major components of the p38 signalling transduction pathway and highlight the targets of this pathway and the physiological function of the p38 activation. (C) 2000 Elsevier Science Inc. All rights reserved.
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