Highly enantioselective [4+2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes

Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of alpha-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.