期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 43, 页码 5259-5261出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc32013d
关键词
-
资金
- National Institutes of Health [R01 GM098435]
- SMART from Office of the Secretary of Defense Test and Evaluation [N00244-09-1-0081]
A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.
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