期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 27, 页码 3357-3359出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17393j
关键词
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资金
- NIH [R01HD065122]
- NSF [CHE-1012511]
- Beckman Young Investigator Award
A library of alpha 2-3- and alpha 2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition.
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