Chiral self-assembly of lactose functionalized perylene bisimides as multivalent glycoclusters

A chiral self-assembly has been constructed from a D-lactose functionalized perylene bisimide derivative, showing right-handed supramolecular stacking induced by the chiral D-lactose moieties. Benefiting from the grafting of D-lactose, the self-assembled multivalent glycoclusters exhibited specific binding with PNA lectin.