Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with beta-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

Hollow mesoporous silica nanoparticles (HMSs) were modified by beta-cyclodextrin via a click reaction, an amphiphilic copolymer with a trans-azobenzene structure was then assembled onto beta-cyclodextrin to cover the surface of the HMSs. The prepared nanocomposites can release drugs in a release-stop-release manner by converting light irradiation.