A self-assembled cage as a non-covalent protective group: regioselectivity control in the nucleophilic substitution of aryl-substituted allylic chlorides

Aryl-substituted allylic chlorides are accommodated by a self-assembled cage in such a restricted orientation that the internal reaction sites are shielded while the external ones are exposed. This non-covalent protection enhances terminal regioselectivity in the allylic substitution.