期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 7, 页码 991-993出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc16220a
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资金
- Imperial Cancer Research UK Centre [C37990/A12196]
- CR-UK&EPSRC Cancer Imaging Centre at Imperial College London [C2536/A10337]
- UK Medical Research Council [U.1200.02.005.00001.01]
- Cancer Research UK [6934, 10337] Funding Source: researchfish
The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [F-18]2-fluoroethylazide ([F-18]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.
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