期刊
CLINICAL NEUROPHARMACOLOGY
卷 23, 期 2, 页码 82-85出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002826-200003000-00004
关键词
amantadine; Parkinson's disease; dyskinesia
We performed a double-blind, placebo-controlled, crossover study to assess the effect of amantadine versus placebo on levodopa-induced dyskinesias in Parkinson's disease. We found a 24% reduction in the total dyskinesia score after amantadine administration (p = 0.004). This improvement was achievement without any influence on the severity of on period parkinsonism. The results confirm that amantadine reduces levodopa dyskinesias and support the hypothesis that dyskinesias can be reduced by blockade of excitatory pathways in the basal ganglia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据