期刊
CHEMICAL COMMUNICATIONS
卷 48, 期 57, 页码 7215-7217出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc33140c
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资金
- National Science Foundation [0755053]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0755053] Funding Source: National Science Foundation
Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.
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