期刊
BREAST CANCER RESEARCH
卷 2, 期 3, 页码 203-210出版社
BMC
DOI: 10.1186/bcr55
关键词
c-Src; epidermal growth factor receptor; human epidermal growth factor receptor 2/neu; signal transducers and activators of transcription; tyrosine phosphorylation
类别
资金
- NCI NIH HHS [R01 CA071449, CA39438, R01 CA039438, CA71449] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA039438, R01CA071449] Funding Source: NIH RePORTER
Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma membrane-associated and involved in mitogenesis, it has been speculated that they function in concert with one another to promote breast cancer development and progression. Evidence to date supports a model wherein c-Src potentiates the survival, proliferation and tumorigenesis of EGF receptor family members, in part by associating with them. Phosphorylation of the EGF receptor by c-SRC is also critical for mitogenic signaling initiated by the EGF receptor itself, as well as by several G-protein coupled receptors (GPCRs), a cytokine receptor, and the estrogen receptor. Thus, c-Src appears to have pleiotropic effects on cancer cells by modulating the action of multiple growth-promoting receptors.
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