期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 3, 页码 944-946出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02924f
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资金
- German Research Foundation (DFG) [SFB 706]
- Baden-Wurttemberg Ministry of Science, Research and the Arts
- Fonds der Chemischen Industrie (Germany)
A minimal enriched P450 BM3 library was screened for the ability to oxidize inert cyclic and acyclic alkanes. The F87A/A328V mutant was found to effectively hydroxylate cyclooctane, cyclodecane and cyclododecane. F87V/A328F with high activity towards cyclooctane hydroxylated acyclic n-octane to 2-(R)-octanol (46% ee) with high regioselectivity (92%).
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