4.7 Article

Active thionium species mediated functionalization at the 2 alpha-position of indole derivatives

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CHEMICAL COMMUNICATIONS
卷 47, 期 23, 页码 6728-6730

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11645b

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  1. Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [S0801043]

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A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2 alpha-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.

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