期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 18, 页码 5316-5318出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10557d
关键词
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资金
- National Basic Research Program of China (973 Program) [2007CB936000]
- National Natural Science Funds for Distinguished Young Scholar [20725518]
- National Key Natural Science Foundation of China [21035003]
- Science and Technology Development Programs of Shandong Province of China [2008GG30003012]
- Key Natural Science Foundation of Shandong Province of China [ZR2010BZ001]
- Science and Technology Planning Project of Higher Education of Shandong Province, China [J10LB02]
A bi-photosensitizer molecular beacon (bi-PS MB) is assembled by coupling two PS molecules, respectively, onto the opposite ends of a single MB. The MB can be triggered by a tumor marker-survivin mRNA. Fluorescence and cytotoxic O-1(2) generation occur effectively in breast cancer cells, but not in normal cells. Compared with a single-PS MB, a bi-PS MB exhibits much-enhanced properties in the signal-to-background ratio and O-1(2) generation simultaneously.
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