期刊
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 5, 期 2, 页码 267-278出版社
MARCEL DEKKER INC
DOI: 10.1081/PDT-100100541
关键词
methacrylate copolymers; microparticles; prednisolone; spray-drying
The aim of this study was to evaluate the influence of operating parameters on the characteristics of methacrylate microparticles prepared by spray-drying technique. Eudragit microparticles were prepared by a spray-drying method. The influence of different experiment parameters (i.e., solvent, feed rate, air-flow rate, air-drying temperature, and aspiration flow rate) on microparticle morphology, size distribution, mid recovery was studied, In addition, different Eudragit types and Eudragit RS concentrations were employed Optical and electron microscopy were employed to analyze microparticle morphology and dimensional distribution. Finally, prednisolone as model drug was encapsulated in Eudragit RS microparticles. Low feed rate values yielded the best results in terms of microparticle morphology. Changes in nebulizing air flow did not result in a corresponding effect on microparticle characteristics. An increase of air-drying temperature resulted in a reduction of microparticle dimension and recovery. A low pow of drying air was preferable because this resulted in microparticles with an optimal morphology. The polymer concentration affected both morphology and dimensions of microparticles. The encapsulation of prednisolone led to goon incorporation efficiencies without altering percentage of recovery, morphology, and mean dimension of the microparticles. The selection of appropriate parameters yielded spray-dried Eudragit RS microparticles characterized by good morphology and narrow dimensional distribution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据