期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 32, 页码 9069-9071出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13146j
关键词
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资金
- National Basic Research Program of China [2010CB732403]
- National Nature Sciences Funding of China [20928005, 41076059, 20905013, 10802062]
- Fujian Province University [JA10011]
A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme.
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