期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 32, 页码 9203-9205出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12127h
关键词
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资金
- NIH [R01 CA136810, R33 CA126659/CA126659Z]
- NATIONAL CANCER INSTITUTE [R33CA126659, R01CA136810] Funding Source: NIH RePORTER
Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.
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