期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 14, 期 2, 页码 S39-S44出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/02698811000142S106
关键词
borderline personality disorder; impulsivity; paraphilias; pathological gambling; sertraline; sexual addictions; SSRIs
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000071] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA010234] Funding Source: NIH RePORTER
- NCRR NIH HHS [5 M01-RR00071] Funding Source: Medline
- NIDA NIH HHS [IR01DA10234-01A2] Funding Source: Medline
Disorders characterized by impulsivity include disorders of impulse control (intermittent explosive disorder, pyromania, kleptomania, pathological gambling and trichotillomania), paraphilias, sexual impulsions and sexual addictions and impulsive aggression personality disorders (borderline, antisocial, histrionic and narcissistic personality disorders). Impulsivity has a substantial impact on both individuals and society. Impulse control, disorders may be conceptualized as a subset of the obsessive-compulsive spectrum. In this article, we examine the genetic and neurobiological aetiology of these disorders and possible treatment options. The link between serotonergic dysfunction and the pathophysiology of impulsivity is discussed, and studies that examine the efficacy of various selective serotonin reuptake inhibitors and other alternatives in the treatment of impulsive disorders such as pathological gambling, sexual addictions and borderline personality disorder are presented.
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