期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 28, 页码 7962-7964出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12570b
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资金
- NIDCR [2R01DE015920-06]
- NIBIB [2R01EB003806-06A2]
- Baxter Early Career Development Award in Bioengineering
- NSF-NSEC
- NSF-MRSEC
- Keck Foundation
- State of Illinois
- Northwestern University
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015920] Funding Source: NIH RePORTER
Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine epsilon-amine allowed for precise placement of a hydrazide in a peptide sequence.
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