期刊
IMMUNOLOGIC RESEARCH
卷 22, 期 2-3, 页码 127-135出版社
HUMANA PRESS INC
DOI: 10.1385/IR:22:2-3:127
关键词
chromatin; enhancer; histones; recombination; thymus; T cell receptor; T lymphocyte
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM041052, R37GM041052] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM41052] Funding Source: Medline
The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene segment accessibility to the recombinase. We have studied the regulation of V(D)J recombination at the TCR alpha/delta locus, because this locus provides a fascinating model in which distinct sets of gene segments are activated at different stages of T cell development. The transcriptional enhancers E delta and E alpha have been implicated as critical regulators that, in conjunction with other cis-acting elements, confer region-specific and developmental-stage-specific changes in gene segment accessibility within TCR alpha/delta locus chromatin. Current work suggests that they may do so by functioning as regional modulators of histone acetylation.
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