期刊
BREAST CANCER RESEARCH
卷 2, 期 6, 页码 423-429出版社
BIOMED CENTRAL LTD
DOI: 10.1186/bcr89
关键词
inflammatory breast cancer; insulin-like growth factor-binding proteins; molecular genetics; RhoC GTPase
类别
资金
- NCI NIH HHS [R01-CA77612, R01 CA077612] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA077612] Funding Source: NIH RePORTER
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologically distinct form of LABC that is particularly fast growing, invasive, and angiogenic. Nearly all women have lymph node involvement at the time of diagnosis, and approximately 36% have gross distant metastases. Despite recent advances in multimodality treatments, the prognosis of patients with IBC is poor, with a median disease-free survival of less than 2.5 years. Recent work on the genetic determinants that underlie the IBC phenotype has led to the identification of genes that are involved in the development and progression of this disease. This work has been aided by the establishment of primary human cell lines and animal models. These advances suggest novel targets for future interventions in the diagnosis and treatment of IBC.
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