Cellular binding of nanoparticles in the presence of serum proteins

Cellular binding of cationic nanoparticles in the presence of serum proteins was probed with two-colour fluorescence micro-scopy. Cationic nanoparticles associate with serum proteins in solution and bind to the cell surface as a single anionic complex. Displacement of serum proteins from the nanoparticles was found to be protein dependent.