4.7 Article

A regio- and stereoselective synthesis of trisubstituted alkenes via gold(I)-catalyzed hydrophosphoryloxylation of haloalkynes

期刊

CHEMICAL COMMUNICATIONS
卷 47, 期 27, 页码 7851-7853

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12052b

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资金

  1. Nanyang Technological University
  2. National Research Foundation of Korea (NRF) [2011-0009011]
  3. Korean government (MEST) [MEST 2009-0087013]
  4. 2nd phase BK21 program

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A new stereoselective synthesis of trisubstituted alkenes is developed. Hydrophosphoryloxylation of haloalkynes provides Z-alkenyl halophosphates, which undergo Pd-catalyzed consecutive cross-coupling reactions to afford regio- and stereodefined trisubstituted alkenes.

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