期刊
IMMUNOLOGIC RESEARCH
卷 21, 期 2-3, 页码 247-251出版社
HUMANA PRESS INC
DOI: 10.1385/IR:21:2-3:247
关键词
lipopolysaccharide; monocytes; nuclear factor-kappa B; inflammation; septic shock
类别
Monocytes become activated at sites of inflammation and contribute to the pathology of many diseases, including septic shock. In these cells, induction of genes expressing various inflammatory mediators, such as cytokines, chemokines, and growth factors, is regulated by nuclear factor-kappa B (NF-kappa B)/Rel transcription factors. Recent studies have identified components of the signal transduction pathways leading to the activation of NF-kappa B/Rel proteins. Inhibition of these signaling pathways provides a novel therapeutic approach to prevent inducible gene expression in monocytes.
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