期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 26, 页码 7458-7460出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11490e
关键词
-
资金
- National Basic Research Program of China (973 Program) [2007CB936000]
- National Natural Science Funds for Distinguished Young Scholar [20725518]
- National Key Natural Science Foundation of China [21035003]
- Science and Technology Development Programs of Shandong Province of China [2008GG30003012]
- Key Natural Science Foundation of Shandong Province of China [ZR2010BZ001]
We demonstrate a tumor mRNA-dependent drug carrier for controlled release of doxorubicin (Dox) and intracellular imaging based on gold nanoparticle-molecular beacon. Fluorescent Dox is released effectively and induces apoptosis in breast cancer cells but not in normal cells. Significantly, the release of Dox is correlated positively with the quantities of tumor mRNA, which is according to various stages of tumor progression, and so can decrease effectively side effects of Dox.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据