期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 39, 页码 11125-11127出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc14706d
关键词
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资金
- Binghamton University
- NIH [R01 GM071461]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM071461] Funding Source: NIH RePORTER
Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.
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