期刊
JOURNAL OF IMMUNOTHERAPY
卷 23, 期 1, 页码 161-167出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002371-200001000-00019
关键词
non-small-cell lung cancer; chemotherapy; radiotherapy; adoptive immunotherapy; tumor-infiltrating lymphocytes
The association of adoptive immunotherapy (AI) and radiotherapy has been shown to be effective in the control of residual intrathoracic disease, while having no systemic advantages, in patients operated on for locally advanced non-small-cell lung cancer (NSCLC). The potential synergy of coupling immunotherapy and chemotherapy has been emphasized in several tumors including NSCLC, The aim of this work was to determine the feasibility and activity of a combined therapeutic program, including Al, chemotherapy, and radiotherapy in patients who had undergone incomplete resections for NSCLC, In a phase II trial, 13 patients received the combined treatment. Al was given from week 4 after surgery until week 8. Concurrent chemo(cisplatin and etoposide)-radiotherapy (60 Gy) was given from week 9 to week 14. Twenty eligible patients received chemoradiotherapy only and were used as a nonrandomized concomitant group for merely descriptive purposes. At 9-month followup, 10 of the 13 patients had progression of disease and the study was stopped. Progression-free survival and survival were similar to those of the chemoradiotherapy group. The present study showed that the sequence of immunotherapy followed by chemotherapy is not effective as adjuvant treatment in patients operated on for stage In. NSCLC, at least when used according to the adopted schedule.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据