期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 22, 页码 6257-6259出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10743g
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资金
- European Union [FP7/2007-2013, 201418 (READNA)]
Templated DNA strand ligation by the ring-strain promoted alkyne-azide [3+2] cycloaddition reaction is very fast; with dibenzocyclooctyne, the reaction is essentially complete in 1 min. It is inhibited by the presence of a single mismatched base pair suggesting applications in genetic analysis.
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