Fluorous silica gel-supported perfluoro-tagged palladium nanoparticles: an efficient and reusable catalyst for direct C-2 arylation of indoles

The preparation of FSG-supported palladium nanoparticles and their application in direct C-2 arylation of indoles are presented. Moderate to good yields were obtained with ultra-low catalyst loading. The catalyst could be easily recovered by simple workup and reused up to seven runs with only a slight decrease in its activity.