期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 6, 页码 1749-1751出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04575f
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资金
- National Institutes of Health [GM065966]
- Defense Threat Reduction Agency [BRBAA08-L-2-0001]
- David and Lucile Packard Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065966] Funding Source: NIH RePORTER
A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn2+ and Mn2+ is switched by only two nucleotide mutations to require Zn2+ alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor.
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