Regulation of chicken haemopoiesis by cytokines

The continuous production. control and functional activation of blood cells involves a complex series of cellular events in which a small population of stem cells generates large numbers of mature cells. The survival, proliferation and development of these cells is strictly dependent on extracellular signals, among these are polypeptide regulators generally known as cytokines. While a large number of mammalian cytokines with proliferative and inhibitory effects have been described in detail, it is surprising that comparatively little is known of the avian system. Given the success of human cytokines as a model, the ability to manipulate the chicken haemopoietic and lymphopoietic systems by precise application of purified cytokines provides a rational approach to defence against disease. As a general caveat, an increased awareness of the existence of regulatory networks and the likelihood that these regulators were designed to function most effectively when acting in combination, will provide an understanding into the regulation of haemopoiesis and hence find application in both clinical and agricultural research. (C) 2000 Elsevier Science Ltd, All rights reserved.