期刊
PHARMACOLOGY
卷 60, 期 1, 页码 51-56出版社
KARGER
DOI: 10.1159/000028347
关键词
paroxetine; risperidone; 9-hydroxyrisperidone; high-performance liquid chromatography electrochemical detection; coulometric detection
A method for the simultaneous determination of paroxetine, risperidone and its main metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multistep solid-phase liquid extraction with an internal standard. The drugs were separated on a cyano column followed by coulometric detection. This method described here has sufficient sensitivity to quantitate paroxetine accurately in the range 5-500 ng/ ml with a lower limit of detection of 1 ng/ml and risperidone and its main metabolite 9-hydroxyrisperidone in the range 2-100 ng/ml with a lower limit of detection of 1 ng/ml when 1 ml of plasma was used for the analysis. The precision, accuracy and specificity have been proven, and show that the method is reliable for clinical studies and routine drug monitoring. Copyright (C) 2000 S. Karger AG, Basel.
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