期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 24, 期 1, 页码 125-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0149-7634(99)00063-9
关键词
dopamine; dopamine receptors; knock-out mice; neuronal disease
Dopamine (DA) is the most abundant catecholamine in the brain. The involvement and importance of DA as a neurotransmitter in the regulation of different physiological functions in the central nervous system (CNS) is well known. Deregulation of the dopaminergic system has been linked with Parkinson's disease, Tourette's syndrome, schizophrenia, attention deficit hyperactive disorder (ADHD) and generation of pituitary tumours. This review focuses on the pharmacological and biochemical features shared by the dopamine receptors. We address their coupling to secondary messenger pathways and their physiological function based upon studies using pharmacological tools, specific brain lesions and, more recently, genetically modified animal models. (C) 2000 Elsevier Science Ltd. All rights reserved.
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