期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 21, 页码 6126-6128出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11163a
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资金
- EC
- Ministero dell'Istruzione, Universita e Ricerca (MIUR) [200858SA98]
- Conseil Regional de Picardie
Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter-and intrafamily comparisons) the effect of their combination is examined. In detail, aromatic substituents were introduced at the 2-N or 30-positions of N-acetyllactosamine and the products conjugated to two types of calix[n] arenes (n = 4, 6) via thiourea-linker chemistry.
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