期刊
BREAST CANCER RESEARCH
卷 2, 期 6, 页码 408-416出版社
BIOMED CENTRAL LTD
DOI: 10.1186/bcr87
关键词
BRMS1; E-cadherin; KAl1; KiSS1; MKK4; Nm23; metastasis; suppressor genes
类别
资金
- NCI NIH HHS [R29 CA69487, P20 CA 66132, R01-CA62168] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA062168, P20CA066132, R29CA069487] Funding Source: NIH RePORTER
The present is an overview of recent data that describes the genetic underpinnings of the suppression of cancer metastasis. Despite the explosion of new information about the genetics of cancer, only six human genes have thus far been shown to suppress metastasis functionally. Not all have been shown to be functional in breast carcinoma. Several additional genes inhibit various steps of the metastatic cascade, but do not necessarily block metastasis when tested using in vivo assays. The implications of this are discussed. Two recently discovered metastasis suppressor genes block proliferation of tumor cells at a secondary site, offering a new target for therapeutic intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据