期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 17, 页码 4998-5000出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc10161g
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资金
- U.S. National Institutes of Health [ES16865]
- Department of Energy [DE-FG02-08ER64568]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES016865] Funding Source: NIH RePORTER
We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast.
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