4.7 Article

Dye-doped silica nanoparticles as efficient labels for glycans

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CHEMICAL COMMUNICATIONS
卷 47, 期 14, 页码 4261-4263

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05299j

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  1. National Institute of General Medical Science (NIGMS) under NIH [1R01GM080295, 2R15GM066279]
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM080295, R15GM066279] Funding Source: NIH RePORTER

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We report that dye-doped fluorescent silica nanoparticles (FSNPs) are highly efficient labels for glycans. Mono- and oligo-saccharides were conjugated to FSNPs using a general photocoupling chemistry. FSNP-labeled glycans were applied to image and detect bacteria, and to study carbohydrate-lectin interactions on a lectin microarray.

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