期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 43, 页码 11873-11875出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15342k
关键词
-
资金
- Medical Research Council [G0001354B, G1000183B] Funding Source: researchfish
- MRC [G0900903, G9439390, G0600986] Funding Source: UKRI
- Medical Research Council [G0600986, G0900903, G9439390, G0001354] Funding Source: Medline
A procedure for the radiosynthesis of aliphatic [F-18] trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [(18) F] fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[F-18] F, has been developed. A variety of F-18-labelled model compounds were then obtained and two potential [F-18] radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2- yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据